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KMID : 0385219930030020116
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Korean Journal of Gerontology
1993 Volume.3 No. 2 p.116 ~ p.122
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Effect of Wild Dropwort Extract on Physiological Activity of Rats
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Choi Jin-Ho
Kim Jae-Il
Kim Dong-Woo
Moon Young-Sil
Yoon Tae-Heon
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Abstract
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The effects of wild dropwort extract(WDE: Oenanthe javanica) orally administered with 0, 25, 50, 100 and 200 ㎎/㎏ BW were compared in physiological activity of Sprague-Dawley rats fed high cholesterol diet for 4 weeks. Body weight gain, feed and gross efficiencies were slightly increased by administration of WDE compared with control group(WDE-0), but there were no significant differences in administered groups of WDE. Administrations of WDE resulted in a marked decreases in serum triglyceride(15∼50%) and total cholesterol(20∼30%) compared with control group(p<0.01∼0.001). LDL cholesterol levels significantly decreased from 58.2±6.7㎎/dl to 33,6±4.4∼45.4±5.7㎎/dl by administration of WDE(20∼35%), but HDL cholesterol levels were no significant differences in administered groups of WDE. Administrations of WDE resulted in a marked increase in HDL cholesterol/total cholesterol(10∼30%), and atherogenic index significantly decreased from 4.89 to 3.53∼4.21 by administrations of WDE(15∼30%). Administrations of WDE resulted in a marked decrease in hydroxyl radical formation, but in a low significant inhibition of serum amlondiadehyde levels(10∼15%). These resulted suggest that wild dropwort extract may be due to inhibition of atherogenic index and malondialdehyde formation with less formation of hydroxyl radical, resulting in a greater decrease in a synthesis of triglyceride, total cholesterol and LDL cholesterol.
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KEYWORD
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wild dropwort, triglyceride(TG), atherogenic index, hydroxyl radical, LDL and HDL cholesterol, malondialdehyde(MDA)
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